Controlling histone methylation via trans-histone pathways
نویسندگان
چکیده
منابع مشابه
Histone H2B C-terminal helix mediates trans-histone H3K4 methylation independent of H2B ubiquitination.
The trans-histone regulatory cross talk between H2BK123 ubiquitination (H2Bub1) and H3K4 and H3K79 methylation is not fully understood. In this study, we report that the residues arginine 119 and threonine 122 in the H2B C-terminal helix are important for transcription and cell growth and play a direct role in controlling H2Bub1 and H3K4 methylation. These residues modulate H2Bub1 levels by con...
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Post-translational addition of methyl groups to the amino-terminal tails of histone proteins was discovered more than three decades ago. Only now, however, is the biological significance of lysine and arginine methylation of histone tails being elucidated. Recent findings indicate that methylation of certain core histones is catalyzed by a family of conserved proteins known as the histone methy...
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ژورنال
عنوان ژورنال: Epigenetics
سال: 2008
ISSN: 1559-2294,1559-2308
DOI: 10.4161/epi.3.5.6869